HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2337Generated: October 26, 2026
Acetic Acid → 3-(Piperidin-1-yl)benzoic acid
https://huagongshe.com/reaction/2337
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Lithium hydroxide, monohydrate | HCID 168937 | — |
| Reactant | Methyl 3-(piperidin-1-yl)benzoate | HCID 7148413 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 3-(Piperidin-1-yl)benzoic acid | HCID 2795552 | 90% |
Reaction Steps
The compound of Example 38 (540 mg, 2.466 mmol) was dissolved in dioxan (12 ml) and water (8 ml). Lithium hydroxide hydrate (300 mg, 7.143 mmol) was added and the mixture stirred at 40° C. for 1 h. The mixture was acidified with acetic acid, evaporated, azeotroped with toluene and chromatographed on silica (eluant 60/40/2, v/v/v, EtOAc/hexanes/AcOH) to provide a colourless solid (450 mg, 90%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05728829 |
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| Source dataset | uspto-grants-1998_03 |
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| ORD ID | ord-227139b0204b412c8ef4f1e745340ffc |
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| Source note | uspto-grants-1998_03 |
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