HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3-Benzyl-1,2,4-oxadiazol-5-ylmethyl)-2-bromo-1-trifluoroacetylaminobenzene → (R)-1(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-(N-(2-bromo-4-(3-benzyl-1,2,4-oxadiazol-5-ylmethyl)phenyl)-N-trifluoroacetylamino)propene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3-Benzyl-1,2,4-oxadiazol-5-ylmethyl)-2-bromo-1-trifluoroacetylaminobenzene | HCID 19702140 | — |
| Reactant | (R)-1-(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene | HCID 54485243 | — |
| Product | (R)-1(N-Benzyloxycarbonylpyrrolidin-2-yl)-3-(N-(2-bromo-4-(3-benzyl-1,2,4-oxadiazol-5-ylmethyl)phenyl)-N-trifluoroacetylamino)propene | HCID 54350671 | 90% |
Reaction Steps
4-(3-Benzyl-1,2,4-oxadiazol-5-ylmethyl)-2-bromo-1-trifluoroacetylaminobenzene and (R)-1-(N-benzyloxycarbonylpyrrolidin-2-yl)-3-hydroxypropene were used. Chromatography using elution with 5% either in methylene chloride afforded the title compound (90%) as a thick yellow oil: R1 =0.75 (CHCl3 --CH3OH 20:1); LRMS (m/z, relative intensity) 683 (M+,18).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05594014 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-d539b91a84bb4fca8d883c1d695702b7 |
| Source note | uspto-grants-1997_01 |