反应详情

5.2 g (62 mmol) of 0-methylhydroxylamine hydrochloride is added to a solution of 10 g (41 mmol) of methyl 2-bromophenylglyoxylate in 30 ml of methanol, and the mixture is refluxed for 2 hours. The mixture is evaporated down, and the residue is taken up in ethyl acetate and washed with water. After drying and evaporating down, there remains 6.9 g (62%) of compound E.

1. temperaturethe mixture is refluxed for 2 hours
2. customThe mixture is evaporated down
3. washwashed with water
4. customAfter drying
5. customevaporating down