反应详情

温度

15 °C

Ethyl carbamate (69.0 g, 774.5 mmol), glyoxylic acid hydrate (71.3 g, 774.5 mmol) and benzotriazole (92.0 g, 774.5 mmol) were dissolved in toluene (2.3 1) and the mixture was heated with distillation for 3 h to precipitate the product. The mixture was diluted with toluene (totally 2.3 1) and stirred at 15° C. overnight. The resultant precipitate was collected by filtration, washed with toluene (160 ml) and dried to afford the title compound (196.06 g, 96%): mp. 189°-192° C.

1. temperaturethe mixture was heated with distillation for 3 h
2. customto precipitate the product
3. additionThe mixture was diluted with toluene (totally 2.3 1) and
4. filtrationThe resultant precipitate was collected by filtration
5. washwashed with toluene (160 ml)
6. customdried