反应详情

(7-Methoxy-1H-indol-3-yl)-dimethyl-sulfonium chloride (0.742 g) prepared in the manner described in Step 1 above was dissolved in DMSO (3 ml) and placed under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask. The flask was placed on a steam bath and heated until the bubbling stopped. When no more starting material was present, the reaction mixture was cooled and partitioned between ether and water. The organic layer was dried and filtered and then evaporated to dryness to afford 7-methoxy-3-methylsulfanyl-1H-indole (0.514 g, 87.5%).

1. customplaced under reduced pressure (house vacuum, ca. 20-50 torr) in a round-bottom flask
2. customThe flask was placed on a steam bath
3. temperatureheated until the bubbling
4. temperaturethe reaction mixture was cooled
5. custompartitioned between ether and water
6. customThe organic layer was dried
7. filtrationfiltered
8. customevaporated to dryness