2-(7-amino-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-N,N-dimethylacetamide → 2-{7-[5-Chloro-4-(4-morpholin-4-yl-2-pyrazol-1-yl-phenylamino)-pyrimidin-2-ylamino]-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-N,N-dimethyl-acetamide

HRID 2338078Notes

Reaction equation

HRID 2338078 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:26])[c:6]([NH:8][c:9]2[c:10](-[n:21]3[n:22][cH:23][cH:24][cH:25]3)[cH:11][c:12]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[cH:13][cH:14]2)[n:7]1.[NH2:27][c:28]1[cH:29][c:30]2[c:31]([cH:43][c:44]1[O:45][CH3:46])[CH2:32][CH2:33][N:34]([CH2:37][C:38](=[O:39])[N:40]([CH3:41])[CH3:42])[CH2:35][CH2:36]2>>[c:2]1([NH:27][c:28]2[cH:29][c:30]3[c:31]([cH:43][c:44]2[O:45][CH3:46])[CH2:32][CH2:33][N:34]([CH2:37][C:38](=[O:39])[N:40]([CH3:41])[CH3:42])[CH2:35][CH2:36]3)[n:3][cH:4][c:5]([Cl:26])[c:6]([NH:8][c:9]2[c:10](-[n:21]3[n:22][cH:23][cH:24][cH:25]3)[cH:11][c:12]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 672635242-(7-amino-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-N,N-dimethylacetamideHCID 86633899(2,5-Dichloro-pyrimidin-4-yl)-(4-morpholin-4-yl-2-pyrazol-1-yl-phenyl)-amine

Product 1

HCID 668307422-{7-[5-Chloro-4-(4-morpholin-4-yl-2-pyrazol-1-yl-phenylamino)-pyrimidin-2-ylamino]-8-methoxy-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl}-N,N-dimethyl-acetamide

Sources & evidence

ORD record
ord-39e59538cfad4cb38b1c0e7bdacdffa3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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