Acetic Anhydride → HCID 23358129, compound

Participants

Reaction Steps

Acetic anhydride is added to a mixture of 2-amino-4,5-dihydroxyindane [Cannon, J. G., et al., J. Med. Chem. 27, 922(1984)] in water containing sodium acetate. The mixture is chilled and stirred in ice for 4 hours followed by filtration to give N-acetyl-2-amino-4,5-dihydroxyindane. Benzylbromide, powdered potassium carbonate and acetone is added to the isolated N-acetyl-2-amino-4,5-dihydroxyindane and the mixture is stirred for 18 hours. The reaction mixture is poured into water, extracted and evaporated in vacuo to give N-acetyl-2-amino-4,5-dibenzyloxyindane. Hydrolysis with ethanolic sodium hydroxide gives 2-amino-4,5-dibenzyloxyindane.

Provenance & Evidence