3-Phenylpyrrolidine → 4-(4-methylpiperazin-1-yl)-6-[7-[(3-phenylpyrrolidin-1-yl)carbonyl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

HRID 2338871Notes

Reaction equation

HRID 2338871 reaction equation
[NH2:1][c:2]1[n:3][c:4]([N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)[cH:5][c:6]([N:8]2[CH2:9][c:10]3[cH:11][c:12]([C:18](=[O:19])[OH:20])[cH:13][cH:14][c:15]3[CH2:16][CH2:17]2)[n:7]1.[c:28]1([CH:34]2[CH2:35][NH:36][CH2:37][CH2:38]2)[cH:29][cH:30][cH:31][cH:32][cH:33]1>>[NH2:1][c:2]1[n:3][c:4]([N:21]2[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]2)[cH:5][c:6]([N:8]2[CH2:9][c:10]3[cH:11][c:12]([C:18](=[O:20])[N:36]4[CH2:35][CH:34]([c:28]5[cH:29][cH:30][cH:31][cH:32][cH:33]5)[CH2:38][CH2:37]4)[cH:13][cH:14][c:15]3[CH2:16][CH2:17]2)[n:7]1

Participants

3

Reactant 2

HCID 31467433-PhenylpyrrolidineHCID 594022702-[2-Amino-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]-1,2,3,4-tetrahydroisoquinoline-7-carboxylic acid

Product 1

HCID 467013224-(4-methylpiperazin-1-yl)-6-[7-[(3-phenylpyrrolidin-1-yl)carbonyl]-3,4-dihydroisoquinolin-2(1H)-yl]pyrimidin-2-amine

Sources & evidence

ORD record
ord-58e939eeae074e99b86f8a72d69936c4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…