2,4-Dichloro-5-fluoropyrimidine → 2-chloro-5-fluoro-N-[4H-imidazo[2,1-c][1,4]-benzoxazin-8-yl]-4-pyrimidineamine

HRID 2339319Notes

Reaction equation

HRID 2339319 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([Cl:8])[n:7]1.[NH2:10][c:11]1[cH:12][cH:13][c:14]2[c:15]([cH:23]1)-[n:16]1[c:17]([n:20][cH:21][cH:22]1)[CH2:18][O:19]2>>[Cl:1][c:2]1[n:3][cH:4][c:5]([F:9])[c:6]([NH:10][c:11]2[cH:12][cH:13][c:14]3[c:15]([cH:23]2)-[n:16]2[c:17]([n:20][cH:21][cH:22]2)[CH2:18][O:19]3)[n:7]1

Participants

3

Reactant 2

HCID 2507052,4-Dichloro-5-fluoropyrimidineHCID 220602028-amino-4H-imidazo[2,1-c][1,4]-benzoxazine

Product 1

HCID 220611002-chloro-5-fluoro-N-[4H-imidazo[2,1-c][1,4]-benzoxazin-8-yl]-4-pyrimidineamine

Sources & evidence

ORD record
ord-7b050d5aefb84b779661569f2d278867
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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