反应详情

2-Nitro-α-toluenesulfonyl chloride (0.943 g, 4.0 mmole) was dissolved in dry dioxane (7 ml) and treated with a solution of dimethylamine (4 ml 2M solution in THF, 8.0 mmole), and stirred at room temperature for a total of 6 h. The reaction mixture was transferred to a separatory funnel and partitioned between ethyl acetate and water. The organic solution was washed with brine, dried over magnesium sulfate, filtered and evaporated to dryness to afford the pure 2-nitrobenzyl-N,N-dimethylsulfonamide, 0.829 g (85% yield).

1. customThe reaction mixture was transferred to a separatory funnel
2. custompartitioned between ethyl acetate and water
3. washThe organic solution was washed with brine
4. dry with materialdried over magnesium sulfate
5. filtrationfiltered
6. customevaporated to dryness