2-nitrobenzyl-N,N-dimethylsulfonamide → HCID 13178727, compound

HRID 23395Notes

Reaction equation

HRID 23395 reaction equation
[N+:1]([C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[CH2:6][S:7]([N:10]([CH3:12])[CH3:11])(=[O:9])=[O:8])([O-])=O>[Pd]>[NH2:1][C:4]1[CH:16]=[CH:15][CH:14]=[CH:13][C:5]=1[CH2:6][S:7]([N:10]([CH3:12])[CH3:11])(=[O:9])=[O:8]

Participants

3

Reactant 1

HCID 131787262-nitrobenzyl-N,N-dimethylsulfonamide

Product 1

HCID 13178727HCID 13178727, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The 2-nitrobenzyl-N,N-dimethylsulfonamide (0.825 g, 3.377 mmole) of Step 1 was dissolved/suspended in alcohol in a Parr hydrogenation bottle. Palladium on charcoal (90 mg, 10% Pd) was added and the mixture was placed under an atmosphere of hydrogen at 45 psi in a Parr shaker. After shaking overnight, the mixture was filtered through Celite and evaporated to dryness to afford 0.693 g pure 2-aminobenzyl-N,N-dimethylsulfonamide (96% yield).

Workup

  1. filtrationthe mixture was filtered through Celite
  2. customevaporated to dryness

Sources & evidence

ORD record
ord-17bcca45b1f247b4b8c6e40e7e9f9671
Source dataset
uspto-grants-2005_02
Patent number
US06852726B2

Reaction notes

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