反应详情

温度

47.5 °C

The 5-chloro-1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-3-[2-(tetrahydro-pyran-2-yloxy)-ethanesulfonyl]-1H-indole (0.028 g) prepared in the previous Step was dissolved in 4 ml acetic acid:water (2:1) and stirred at 45-50° C. for 3 h. The solvents were removed under reduced pressure and the crude product was purified by column chromatography (silica gel) eluting with 3-5% methanol in methylene chloride with 0.1% ammonium hydroxide added. The 2-[5-Chloro-1-(4,5-dihydro-1H-imidazol-2-ylmethyl)-1H-indole-3-sulfonyl]-ethanol thus obtained weighed 0.005 g after drying.

1. customThe solvents were removed under reduced pressure
2. customthe crude product was purified by column chromatography (silica gel)
3. washeluting with 3-5% methanol in methylene chloride with 0.1% ammonium hydroxide
4. additionadded