反应详情

A solution of (2,5-dichloro-3-methylsulfonyl-indol-1-yl)-acetonitrile (0.303 g, 1 mmole) in dry chloroform (15 ml) was cooled to 0° C. under a nitrogen atmosphere. To this solution was added anhydrous ethanol (0.35 ml). Dry hydrogen chloride gas was bubbled into the reaction mixture to saturation at 0° C. The flask was stoppered and stirred for 2 h at 0 and left in the freezer overnight. The resulting white solid precipitate was filtered off and dried to afford 0.353 g (91%) of 2-(2,5-dichloro-3-methanesulfonyl-indol-1-yl)-acetimidic acid ethyl ester hydrochloride.

1. customDry hydrogen chloride gas was bubbled into the reaction mixture to saturation at 0° C
2. waitleft in the freezer overnight
3. filtrationThe resulting white solid precipitate was filtered off
4. customdried