N-ethylformamide ethylamine → 4'-[[2-n-Propyl-4-methyl-6-(1-ethyl-4-isopropyl-5-methyl-imidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic Acid

HRID 234028Notes

Reaction equation

HRID 234028 reaction equation
[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:15]=[CH:14][C:13]([C:16]3[C:17]([C:22]([O:24]C(C)(C)C)=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:12][CH:11]=2)[C:7]2[CH:29]=[C:30]([C:34]3O[C:36]([CH3:42])=[C:37]([CH:39]([CH3:41])[CH3:40])[N:38]=3)[CH:31]=[C:32]([CH3:33])[C:6]=2[N:5]=1)[CH2:2][CH3:3].[CH2:43]([NH:45]C=O)[CH3:44].C(N)C>>[CH2:1]([C:4]1[N:8]([CH2:9][C:10]2[CH:11]=[CH:12][C:13]([C:16]3[C:17]([C:22]([OH:24])=[O:23])=[CH:18][CH:19]=[CH:20][CH:21]=3)=[CH:14][CH:15]=2)[C:7]2[CH:29]=[C:30]([C:34]3[N:45]([CH2:43][CH3:44])[C:36]([CH3:42])=[C:37]([CH:39]([CH3:41])[CH3:40])[N:38]=3)[CH:31]=[C:32]([CH3:33])[C:6]=2[N:5]=1)[CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 20318569N-ethylformamide ethylamineHCID 67708445tert.butyl 4'-[[2-n-propyl-4-methyl-6-(4-isopropyl-5-methyl-oxazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate

Product 1

HCID 544728254'-[[2-n-Propyl-4-methyl-6-(1-ethyl-4-isopropyl-5-methyl-imidazol-2-yl)-1H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylic Acid

Procedure

Prepared analogously to Example 146 from tert.butyl 4'-[[2-n-propyl-4-methyl-6-(4-isopropyl-5-methyl-oxazol-2-yl)-l H-benzimidazol-1-yl]-methyl]-biphenyl-2-carboxylate and N-ethyl-formamide/ethylamine.

Sources & evidence

ORD record
ord-ac58506e35574de8a924b851fa31299f
Source dataset
uspto-grants-1997_01
Patent number
US05594003

Reaction notes

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