1-(3,5-Difluoropyridin-2-yl)ethan-1-amine → 6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-[1-(3,5-difluoro-2-pyridinyl)ethylamino]-5-fluoropyridine-3-carbonitrile

HRID 2340549Notes

Reaction equation

HRID 2340549 reaction equation
[CH:1]1([c:4]2[cH:5][c:6]([NH:9][c:10]3[n:11][c:12]([F:19])[c:13]([C:14]#[N:15])[cH:16][c:17]3[F:18])[n:7][nH:8]2)[CH2:2][CH2:3]1.[F:20][c:21]1[c:22]([CH:28]([CH3:29])[NH2:30])[n:23][cH:24][c:25]([F:27])[cH:26]1>>[CH:1]1([c:4]2[cH:5][c:6]([NH:9][c:10]3[n:11][c:12]([NH:30][CH:28]([c:22]4[c:21]([F:20])[cH:26][c:25]([F:27])[cH:24][n:23]4)[CH3:29])[c:13]([C:14]#[N:15])[cH:16][c:17]3[F:18])[n:7][nH:8]2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 583673901-(3,5-Difluoropyridin-2-yl)ethan-1-amineHCID 674265316-(5-cyclopropyl-1H-pyrazol-3-ylamino)-2,5-difluoronicotinonitrile

Product 1

HCID 730385866-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-2-[1-(3,5-difluoro-2-pyridinyl)ethylamino]-5-fluoropyridine-3-carbonitrile

Sources & evidence

ORD record
ord-6766a6153520419d827e7083ae9d215c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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