Carbonate Ion → methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate

HRID 2340594Notes

Reaction equation

HRID 2340594 reaction equation
[Br:27][c:28]1[cH:29][c:30]([F:35])[cH:31][c:32]([F:34])[cH:33]1.[C:36](=[O:37])([O-:38])[O-:39].[CH2:42]1[O:43][CH2:44][CH2:45][O:46][CH2:47]1.[Cs+:40].[Cs+:41].[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[o:8][c:9]3[c:10]([CH:22]4[NH:23][CH2:24][CH2:25][CH2:26]4)[cH:11][c:12]([C:18](=[O:19])[O:20][CH3:21])[cH:13][c:14]3[c:15](=[O:17])[cH:16]2)[CH2:5][CH2:6]1.[Pd:48]>>[O:1]1[CH2:2][CH2:3][N:4]([c:7]2[o:8][c:9]3[c:10]([CH:22]4[N:23]([c:28]5[cH:29][c:30]([F:35])[cH:31][c:32]([F:34])[cH:33]5)[CH2:24][CH2:25][CH2:26]4)[cH:11][c:12]([C:18](=[O:19])[O:20][CH3:21])[cH:13][c:14]3[c:15](=[O:17])[cH:16]2)[CH2:5][CH2:6]1

Participants

7

Reactant 6

HCID 19660Carbonate IonHCID 23938PalladiumHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 1363131-Bromo-3,5-difluorobenzeneHCID 86672405methyl 2-morpholino-4-oxo-8-(pyrrolidin-2-yl)-4H-chromene-6-carboxylate

Product 1

HCID 86672406methyl 8-(1-(3,5-difluorophenyl)pyrrolidin-2-yl)-2-morpholino-4-oxo-4H-chromene-6-carboxylate

Sources & evidence

ORD record
ord-9b68d636d52f4ddb97e3f475178064ea
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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