Dichloromethane → tert-butyl (3RS,4RS)-4-(4-methoxycarbonylmethyl-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

HRID 2340634Notes

Reaction equation

HRID 2340634 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([O:24][CH2:25][c:26]2[cH:27][c:28]3[cH:29][cH:30][cH:31][cH:32][c:33]3[cH:34][cH:35]2)[CH:11]([c:14]2[cH:15][cH:16][c:17]([CH2:20][C:21](=[O:22])[OH:23])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH2:39]([Cl:40])[Cl:41].[N+:36](=[N-:37])=[CH2:38]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH:10]([O:24][CH2:25][c:26]2[cH:27][c:28]3[cH:29][cH:30][cH:31][cH:32][c:33]3[cH:34][cH:35]2)[CH:11]([c:14]2[cH:15][cH:16][c:17]([CH2:20][C:21]([O:22][CH3:38])=[O:23])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 9550DiazomethaneHCID 22128103(3RS,4RS)-[4-(1-tert-butoxycarbonyl-3-naphthalen-2-ylmethoxy-piperidin-4-yl)-phenyl]-acetic acid

Product 1

HCID 54460902tert-butyl (3RS,4RS)-4-(4-methoxycarbonylmethyl-phenyl)-3-(naphthalen-2-ylmethoxy)-piperidine-1-carboxylate

Sources & evidence

ORD record
ord-a46613127e864f618c603073ce6cbbb8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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