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Diisopropylethylamine → 2-[4-(5-Bromo-2-methoxybenzyl)-1-piperazinyl]pyrimidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4-Bromo-2-(chloromethyl)-1-methoxybenzene | HCID 10354068 | — |
| 反応物 | 2-Piperazinylpyrimidine dihydrochloride | HCID 11680272 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | 2-[4-(5-Bromo-2-methoxybenzyl)-1-piperazinyl]pyrimidine | HCID 1240303 | 235% |
反応手順
A mixture of 1.1 g of 2-(chloromethyl)-4-bromoanisole, 1 g of 1-(2-pyrimidyl)piperazine dihydrochloride and 2.0 mL N,N-diisopropylethylamine in 10 mL chloroform was heated at reflux temperature for 2 hr, cooled to room temperature, washed with 1N NaOH and water. The solvent was removed by evaporation under reduced pressure to yield 3.6 g of 2-[(4-(2-pyrimidinyl)-piperazinyl)methyl]-4-bromoanisole as a white solid which was used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05594141 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-50c7e7e5bd1142ff86cca652ef994649 |
| 出典メモ | uspto-grants-1997_01 |