3-(2-Methoxyethyl)-2,3,4,5-tetrahydro-1h-3-benzazepin-7-amine → 5-Bromo-2-{5-chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]-pyrimidin-4-ylamino}-3-fluoro-N-methyl-benzamide

HRID 2341426Notes

Reaction equation

HRID 2341426 reaction equation
[Br:17][c:18]1[cH:19][c:20]([F:37])[c:21]([NH:28][c:29]2[n:30][c:31]([Cl:36])[n:32][cH:33][c:34]2[Cl:35])[c:22]([C:23](=[O:24])[NH:25][CH3:26])[cH:27]1.[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:12][c:13]([NH2:16])[cH:14][cH:15]2)[CH2:10][CH2:11]1>>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[CH2:6][CH2:7][c:8]2[c:9]([cH:12][c:13]([NH:16][c:31]3[n:30][c:29]([NH:28][c:21]4[c:20]([F:37])[cH:19][c:18]([Br:17])[cH:27][c:22]4[C:23](=[O:24])[NH:25][CH3:26])[c:34]([Cl:35])[cH:33][n:32]3)[cH:14][cH:15]2)[CH2:10][CH2:11]1

Participants

3

Reactant 2

HCID 574160893-(2-Methoxyethyl)-2,3,4,5-tetrahydro-1h-3-benzazepin-7-amineHCID 866340355-bromo-2-(2,5-dichloro-pyrimidin-4-ylamino)-3-fluoro-N-methyl-benzamide

Product 1

HCID 668305265-Bromo-2-{5-chloro-2-[3-(2-methoxy-ethyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ylamino]-pyrimidin-4-ylamino}-3-fluoro-N-methyl-benzamide

Sources & evidence

ORD record
ord-be69d114fd044f7987ef8ad305320fba
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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