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Sodium Azide → 2-Azido-1-(3,4-dihydroxyphenyl)ethanone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Azide | HCID 33557 | — |
| 反応物 | 2-Chloro-3',4'-dihydroxyacetophenone | HCID 66834 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 2-Azido-1-(3,4-dihydroxyphenyl)ethanone | HCID 21466031 | 90% |
反応手順
To the solution of 4-chloroacetylcatechol (25 g) in DMF (200 ml) was added sodium azide (10.5 g), and the mixture was stirred at room temperature for 1 hour. The reaction mixture was diluted with ethyl acetate, washed with water and dried over anhydrous magnesium sulfate. After the solvent was evaporated, the solids thus obtained was washed with a solution of n-hexane:ether=5:1 to give 23.2 g of 4-azidoacetylcatechol (yield, 90%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05594004 |
| 出典データセット | uspto-grants-1997_01 |
| ORD ID | ord-afab536b3d874b7c898e921e9c48c510 |
| 出典メモ | uspto-grants-1997_01 |