Sodium Hydroxide → HCID 21466074, compound

Participants

Reaction Steps

To the solution of the compound prepared in (a) (250 mg) in ethanol was added 1N sodium hydroxide (2.6 ml), and the mixture was stirred under ice-cooling for 3 hours. After the reaction mixture was concentrated under reduced pressure, ethyl acetate and water were added. The mixture was acidified with 1N hydrochloric acid. The organic layer was washed with water, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give 214 mg of 4-[2-[[(5-t-butoxycarbonyl-4,5,6,7-tetrahydrothieno[3,2 -c]pyridin-2 -yl)carbonyl]amino]ethyl]phenoxyacetic acid (yield, 91% ).

Provenance & Evidence