2,2-Difluoro-2-phenylacetic acid → N-{3-[1-(3-{[difluoro(phenyl)acetyl]amino}propyl)-4-piperidinyl]-4-methylphenyl}-2-methylpropanamide
Reaction equation
[F:1][C:2]([C:3](=[O:4])[OH:5])([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[F:12].[NH2:13][CH2:14][CH2:15][CH2:16][N:17]1[CH2:18][CH2:19][CH:20]([c:23]2[cH:24][c:25]([NH:30][C:31]([CH:32]([CH3:33])[CH3:34])=[O:35])[cH:26][cH:27][c:28]2[CH3:29])[CH2:21][CH2:22]1>>[F:1][C:2]([C:3](=[O:5])[NH:13][CH2:14][CH2:15][CH2:16][N:17]1[CH2:18][CH2:19][CH:20]([c:23]2[cH:24][c:25]([NH:30][C:31]([CH:32]([CH3:33])[CH3:34])=[O:35])[cH:26][cH:27][c:28]2[CH3:29])[CH2:21][CH2:22]1)([c:6]1[cH:7][cH:8][cH:9][cH:10][cH:11]1)[F:12]Participants
3
Sources & evidence
- ORD record
- ord-a72ecc8005bb4ec89767cc2f5a87922f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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