1-Butanol → 1-[3-(4-Ethyl-2-methoxyphenoxy)propyl]-alpha,alpha-bis (4-fluorophenyl)-4-piperidinemethanol
Reaction equation
[CH2:23]([CH3:24])[c:25]1[cH:26][c:27]([O:36][CH3:37])[c:28]([O:29][CH2:30][CH2:31][CH2:32][Cl:33])[cH:34][cH:35]1.[CH2:46]([OH:47])[CH2:48][CH2:49][CH3:50].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]([OH:9])([CH:10]2[CH2:11][CH2:12][NH:13][CH2:14][CH2:15]2)[c:16]2[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]2)[cH:6][cH:7]1.[I-:45].[K+:44].[Na+:38].[Na+:39].[O-:40][C:41](=[O:42])[O-:43]>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8]([OH:9])([CH:10]2[CH2:11][CH2:12][N:13]([CH2:32][CH2:31][CH2:30][O:29][c:28]3[c:27]([O:36][CH3:37])[cH:26][c:25]([CH2:23][CH3:24])[cH:35][cH:34]3)[CH2:14][CH2:15]2)[c:16]2[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]2)[cH:6][cH:7]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-357aee32a2ac43a4a16d127a73ba92e8
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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