反应详情

4-Amino-2,3,5-trimethylphenol (100 g, 662 mmol) was dissolved in formic acid (500 ml). The mixture was heated under reflux for 36 hours. The reaction mixture was poured into ice-cold water. The precipitated crystals were filtered, washed with water and dried. The crude crystals obtained were recrystallized from ethanol to obtain the desired compound (85.9 g, yield: 72.5%), m.p. 219°-220° C.

1. temperatureThe mixture was heated
2. temperatureunder reflux for 36 hours
3. additionThe reaction mixture was poured into ice-cold water
4. filtrationThe precipitated crystals were filtered
5. washwashed with water
6. customdried
7. customThe crude crystals obtained
8. customwere recrystallized from ethanol