Acetic Acid → Methyl 3-amino-6-fluoropyrazine-2-carboxylate

HRID 2342945Notes

Reaction equation

HRID 2342945 reaction equation
[C:21](=[O:22])([O-:23])[O-:24].[C:27](=[O:28])([O-:29])[O-:30].[CH3:17][C:18](=[O:19])[OH:20].[Ca+2:25].[F:1][c:2]1[cH:3][n:4][c:5]([N+:12]([O-:13])=[O:14])[c:6]([C:8](=[O:9])[O:10][CH3:11])[n:7]1.[H:15][H:16].[Pd+2:26]>>[F:1][c:2]1[cH:3][n:4][c:5]([NH2:12])[c:6]([C:8](=[O:9])[O:10][CH3:11])[n:7]1

Participants

7

Reactant 6

HCID 176Acetic AcidHCID 271Calcium CationHCID 19660Carbonate Ion2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 22662836Methyl 6-fluoro-3-nitro-2-pyrazinecarboxylateHCID 178418361HCID 178418361, compound

Product 1

HCID 22662844Methyl 3-amino-6-fluoropyrazine-2-carboxylate

Sources & evidence

ORD record
ord-648e22f0efc74899b83cc178d0d63716
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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