反应详情

A stirred mixture of 2-n-butyl-4-chloro-5-hydroxymethylimidazole (15.00 g, 0.0795 mol) and activated manganese dioxide (40.00 g) in 600 ml of methylene chloride was refluxed for 24 h using a water separator. The mixture was filtered hot through a Celite® pad. The Celite® pad was washed several times with hot methylene chloride. The washings were combined with the filtrate and concentrated in vacuo to give 12.81 g (86%) of the aldehyde as a white solid; mp 97°-98° C.

1. temperaturewas refluxed for 24 h
2. filtrationThe mixture was filtered hot through a Celite® pad
3. washThe Celite® pad was washed several times with hot methylene chloride
4. concentrationconcentrated in vacuo