HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,5-Dichlorothiophene-3-sulfonyl chloride → N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichlorothiophene-3-sulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,5-Dichlorothiophene-3-sulfonyl chloride | HCID 2736094 | — |
| Reactant | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| Product | N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichlorothiophene-3-sulfonamide | HCID 15342064 | 47% |
Reaction Steps
N-(4-Bromo-3-methyl-5-isoxazolyl)-2,5-dichlorothiophene-3-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and 2,5-dichlorothiophene-3-sulphonyl chloride in 47% yield. Purification was achieved by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 135°-138° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05594021 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-451f5ebd67574ae98b00f67cf3b07dec |
| Source note | uspto-grants-1997_01 |