HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 23445291, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 4-Bromo-3-methylisoxazol-5-amine | HCID 10487519 | — |
| Reactant | 2-Ethylbenzo[b]thiophene-3-sulfonyl chloride | HCID 22998406 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 23445291 | HCID 23445291 | — |
Reaction Steps
N-(4-bromo-3-methyl-5-isoxazolyl)-2-ethylbenzo[b]thiophene-3-sulfonamide was prepared by the method of Example 41 with 4-bromo-3-methyl-5-aminoisoxazole (1.0 mmoles, 0.177 g), NaH (2.5 mmoles, 100 mg), 2-ethylbenzo[b]thiophene-3-sulfonyl chloride (1.2 mmoles, 0.31 g) and THF (7 ml). Recrystallization from chloroform and hexanes provided 0.24 g (60%) of a tan crystalline solid, m.p. 118.5°-120° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05594021 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-080036b838db46bf908f8c48ba614471 |
| Source note | uspto-grants-1997_01 |