3-Pyridinemethanamine → 4-methyl-2-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide

HRID 2343330Notes

Reaction equation

HRID 2343330 reaction equation
[CH2:1]([N:2]1[CH2:3][CH2:4][N:5]([c:6]2[s:7][c:8]([C:9]([OH:10])=[O:11])[c:12]([CH3:13])[n:14]2)[C:15]1=[O:16])[c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1.[CH3:23][c:24]1[n:25][c:26]([N:32]2[C:33](=[O:48])[N:34]([CH2:37][c:38]3[cH:39][cH:40][c:41]([C:44]([F:45])([F:46])[F:47])[cH:42][cH:43]3)[CH2:35][CH2:36]2)[s:27][c:28]1[C:29](=[O:30])[OH:31].[NH2:49][CH2:50][c:51]1[cH:52][n:53][cH:54][cH:55][cH:56]1>>[CH3:23][c:24]1[n:25][c:26]([N:32]2[C:33](=[O:48])[N:34]([CH2:37][c:38]3[cH:39][cH:40][c:41]([C:44]([F:45])([F:46])[F:47])[cH:42][cH:43]3)[CH2:35][CH2:36]2)[s:27][c:28]1[C:29](=[O:31])[NH:49][CH2:50][c:51]1[cH:52][n:53][cH:54][cH:55][cH:56]1

Participants

4

Reactant 3

HCID 310183-PyridinemethanamineHCID 579198662-(3-Benzyl-2-oxoimidazolidin-1-yl)-4-methylthiazole-5-carboxylic acidHCID 579199574-Methyl-2-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)thiazole-5-carboxylic acid

Product 1

HCID 250951484-methyl-2-(2-oxo-3-(4-(trifluoromethyl)benzyl)imidazolidin-1-yl)-N-(pyridin-3-ylmethyl)thiazole-5-carboxamide

Sources & evidence

ORD record
ord-2d23e989dada49daa6140bd78e1f921d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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