4-Bromo-3-methylisoxazol-5-amine → HCID 22998506, compound

HRID 234356Notes

Reaction equation

HRID 234356 reaction equation
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[S:9]1[CH:13]=[CH:12][N:11]=[C:10]1[S:14](Cl)(=[O:16])=[O:15]>>[Br:8][C:3]1[C:4]([CH3:7])=[N:5][O:6][C:2]=1[NH:1][S:14]([C:10]1[S:9][CH:13]=[CH:12][N:11]=1)(=[O:16])=[O:15]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 115792352-Thiazolesulfonyl chloride

Product 1

HCID 22998506HCID 22998506, compoundYield 57%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)thiazole-2-sulfonamide was prepared in the same manner as described in Example 2 from 5-amino-4-bromo-3-methylisoxazole and thiazole-2-sulfonyl chloride in 57% yield. This was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.) to give a solid., m.p. 175°-177° C.

Workup

  1. customThis was purified by HPLC (5% CH3CN to 100% CH3CN over 30 min.)
  2. customto give a solid

Sources & evidence

ORD record
ord-7e0a62064e004ef49764697155cb96ea
Source dataset
uspto-grants-1997_01
Patent number
US05594021

Reaction notes

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