反应详情

A mixture of 4.65 g (30 mmol) of crude 5-(hydroxymethyl)-4-isopropyl-thiazole in 200 mL of chloroform (CHCl3) was treated with 45 g of MnO2 and stirred at room temperature for 2.5 hours. The suspension was filtered, and the filtrate was concentrated. The residue was chromatographed on silica gel, eluting with 3:1 hexane:EtOAc, to give the title compound.

1. filtrationThe suspension was filtered
2. concentrationthe filtrate was concentrated
3. customThe residue was chromatographed on silica gel
4. washeluting with 3:1 hexane