HCID 10909824, compound → 4-Isopropylthiazole-5-carbaldehyde

HRID 23439Notes

Reaction equation

HRID 23439 reaction equation
[OH:1][CH2:2][C:3]1[S:7][CH:6]=[N:5][C:4]=1[CH:8]([CH3:10])[CH3:9]>C(Cl)(Cl)Cl.O=[Mn]=O>[CH:8]([C:4]1[N:5]=[CH:6][S:7][C:3]=1[CH:2]=[O:1])([CH3:10])[CH3:9]

Participants

4

Reactant 1

HCID 10909824HCID 10909824, compound

Product 1

HCID 110841114-Isopropylthiazole-5-carbaldehyde

Reagents, catalysts & solvents 2

HCID 14801Manganese dioxideCatalystHCID 6212ChloroformSolvent

Procedure

A mixture of 4.65 g (30 mmol) of crude 5-(hydroxymethyl)-4-isopropyl-thiazole in 200 mL of chloroform (CHCl3) was treated with 45 g of MnO2 and stirred at room temperature for 2.5 hours. The suspension was filtered, and the filtrate was concentrated. The residue was chromatographed on silica gel, eluting with 3:1 hexane:EtOAc, to give the title compound.

Workup

  1. filtrationThe suspension was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was chromatographed on silica gel
  4. washeluting with 3:1 hexane

Sources & evidence

ORD record
ord-06b404f5eb48426282f938d4be47ae15
Source dataset
uspto-grants-2005_02
Patent number
US06852711B2

Reaction notes

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