HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosulfonic acid → 2-Ethylbenzo[b]furan-3-sulfonyl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosulfonic acid | HCID 24638 | — |
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 2-Ethylbenzofuran | HCID 76582 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Ethylbenzo[b]furan-3-sulfonyl chloride | HCID 22998408 | — |
Reaction Steps
2-Ethylbenzo[b]furan-3-sulfonyl chloride was prepared by the method of Example 82C with 2-ethylbenzo[b]furan (6.9 mmols, 1.0 g), chlorosulfonic acid (8.9 mmols, 0.6 ml) phosphorous oxychloride (21 mmols, 1.9 ml), phosphorous pentachloride (6.9 mmols, 1.4 g) and CH2Cl2 (10 ml). Flash chromatography (2% ethyl acetate/hexanes) provided 0.71 g (42%) of an orange solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05594021 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-6bbbd6bb37f840c49a7453d254ec080f |
| Source note | uspto-grants-1997_01 |