2-Bromothiophene → 2-(3-methylphenyl)thiophene

HRID 234426Notes

Reaction equation

HRID 234426 reaction equation
Br[C:2]1[S:3][CH:4]=[CH:5][CH:6]=1.[CH3:7][C:8]1[CH:9]=[C:10](B(O)O)[CH:11]=[CH:12][CH:13]=1>>[C:8]1([CH3:7])[CH:9]=[CH:10][CH:11]=[C:12]([C:2]2[S:3][CH:4]=[CH:5][CH:6]=2)[CH:13]=1

Participants

3

Reactant 2

HCID 138512-BromothiopheneHCID 27339503-Tolylboronic acid

Product 1

HCID 35641882-(3-methylphenyl)thiophene

Procedure

2-(3-tolyl)thiophene was prepared in the same manner as described in Example 117A using 2-bromothiophene and 3-methylphenylboronic acid. The crude product was purified by flash chromatography on silica gel using hexane as the eluent (86% yield).

Workup

  1. customThe crude product was purified by flash chromatography on silica gel

Sources & evidence

ORD record
ord-91a243f7ed91459fb6fa0fa112098ea5
Source dataset
uspto-grants-1997_01
Patent number
US05594021

Reaction notes

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