4-Bromo-3-methylisoxazol-5-amine → HCID 23445315, compound

HRID 234440Notes

Reaction equation

HRID 234440 reaction equation
Cl[S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[CH2:10]/[CH:11]=[CH:12]/[C:13]1[CH:18]=[CH:17][C:16]2[O:19][CH2:20][O:21][C:15]=2[CH:14]=1)(=[O:4])=[O:3].[NH2:22][C:23]1[O:27][N:26]=[C:25]([CH3:28])[C:24]=1[Br:29]>>[Br:29][C:24]1[C:25]([CH3:28])=[N:26][O:27][C:23]=1[NH:22][S:2]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[CH2:10]/[CH:11]=[CH:12]/[C:13]1[CH:18]=[CH:17][C:16]2[O:19][CH2:20][O:21][C:15]=2[CH:14]=1)(=[O:4])=[O:3]

Participants

3

Reactant 2

HCID 104875194-Bromo-3-methylisoxazol-5-amineHCID 23445331HCID 23445331, compound

Product 1

HCID 23445315HCID 23445315, compoundYield 33%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)-2-[trans-3,4-(methylenedioxy)cinnamyl]thiophene-3-sulfonamide was prepared in the same manner as described in Example 1 by reaction of 3-chlorosulfonyl-2-[trans-3,4-(methylenedioxy)cinnamyl]thiophene with 5-amino-4-bromo-3-methylisoxazole. The crude product was purified by HPLC resulting in a 33% yield, m.p. 147°-149° C.

Workup

  1. customThe crude product was purified by HPLC
  2. customresulting in a 33% yield, m.p. 147°-149° C.

Sources & evidence

ORD record
ord-ce6cb9bc32bc46b98ea6d9167dd16390
Source dataset
uspto-grants-1997_01
Patent number
US05594021

Reaction notes

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