Tolylboronic acid → HCID 23445394, compound

HRID 234446Notes

Reaction equation

HRID 234446 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.Br[C:12]1[S:16][C:15]([S:17]([N:20]2[CH:24]=[CH:23][CH:22]=[CH:21]2)(=[O:19])=[O:18])=[CH:14][CH:13]=1>>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:12]2[S:16][C:15]([S:17]([N:20]3[CH:24]=[CH:23][CH:22]=[CH:21]3)(=[O:18])=[O:19])=[CH:14][CH:13]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 79799Tolylboronic acidHCID 23445587N-(5-bromothiophenesulfonyl)pyrrole

Product 1

HCID 23445394HCID 23445394, compound

Procedure

N-[5-(4-methylphenyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 32C using 4-methyl-phenylboronic acid and N-(5-bromothiophenesulfonyl)pyrrole. Purification by column chromatography using 2% ethyl acetate/hexanes gave N-[5-(4-methylphenyl)thiophene-2-sulfonyl]pyrrole as a pale yellow solid in 77% yield.

Workup

  1. customN-[5-(4-methylphenyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner
  2. customPurification by column chromatography

Sources & evidence

ORD record
ord-0c102bb41af1487a80c8ad5409671aab
Source dataset
uspto-grants-1997_01
Patent number
US05594021

Reaction notes

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