Dichloromethane → tert-butyl N-[4-[[1-cyano-2-[4-[3-(2-methoxyethyl)-2-oxo-1,3-benzothiazol-5-yl]phenyl]ethyl]carbamoyl]oxan-4-yl]carbamate

HRID 2344550Notes

Reaction equation

HRID 2344550 reaction equation
[Cl:43][CH2:44][Cl:45].[NH2:1][C:2]([CH:3]([CH2:4][c:5]1[cH:6][cH:7][c:8](-[c:11]2[cH:12][cH:13][c:14]3[c:15]([n:16]([CH2:20][CH2:21][O:22][CH3:23])[c:17](=[O:19])[s:18]3)[cH:24]2)[cH:9][cH:10]1)[NH:25][C:26](=[O:27])[C:28]1([NH:34][C:35]([O:36][C:37]([CH3:38])([CH3:39])[CH3:40])=[O:41])[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1)=[O:42]>>[N:1]#[C:2][CH:3]([CH2:4][c:5]1[cH:6][cH:7][c:8](-[c:11]2[cH:12][cH:13][c:14]3[c:15]([n:16]([CH2:20][CH2:21][O:22][CH3:23])[c:17](=[O:19])[s:18]3)[cH:24]2)[cH:9][cH:10]1)[NH:25][C:26](=[O:27])[C:28]1([NH:34][C:35]([O:36][C:37]([CH3:38])([CH3:39])[CH3:40])=[O:41])[CH2:29][CH2:30][O:31][CH2:32][CH2:33]1

Participants

3

Reactant 2

HCID 6344DichloromethaneHCID 72328341tert-butyl N-[4-[[1-amino-3-[4-[3-(2-methoxyethyl)-2-oxo-1,3-benzothiazol-5-yl]phenyl]-1-oxopropan-2-yl]carbamoyl]oxan-4-yl]carbamate

Product 1

HCID 72328350tert-butyl N-[4-[[1-cyano-2-[4-[3-(2-methoxyethyl)-2-oxo-1,3-benzothiazol-5-yl]phenyl]ethyl]carbamoyl]oxan-4-yl]carbamate

Sources & evidence

ORD record
ord-2455cd21186b4418b7174132ad2adbf1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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