Acetate → Tert-butyl (1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

HRID 2344577Notes

Reaction equation

HRID 2344577 reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]2[cH:7][cH:8][c:9]([CH:12]3[O:13][C:14]([CH3:17])([CH3:18])[O:15][CH2:16]3)[n:10][c:11]12.[C:34](=[O:35])([O-:36])[O-:37].[CH3:40][c:41]1[cH:42][cH:43][cH:44][cH:45][cH:46]1.[Cs+:38].[Cs+:39].[NH:19]1[CH2:20][CH2:21][CH:22]([CH2:25][NH:26][C:27]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:33])[CH2:23][CH2:24]1.[O-:48][C:49]([CH3:50])=[O:51].[O-:52][C:53]([CH3:54])=[O:55].[Pd+2:47]>>[c:2]1([N:19]2[CH2:20][CH2:21][CH:22]([CH2:25][NH:26][C:27]([O:28][C:29]([CH3:30])([CH3:31])[CH3:32])=[O:33])[CH2:23][CH2:24]2)[cH:3][cH:4][cH:5][c:6]2[cH:7][cH:8][c:9]([CH:12]3[O:13][C:14]([CH3:17])([CH3:18])[O:15][CH2:16]3)[n:10][c:11]12

Participants

8

Reactant 7

HCID 175Acetate2×HCID 1140TolueneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 723429Tert-butyl (piperidin-4-ylmethyl)carbamateHCID 672343698-Bromo-2-(2,2-dimethyl-1,3-dioxolan-4-yl)quinoline

Product 1

HCID 86654343Tert-butyl (1-(2-(2,2-dimethyl-1,3-dioxolan-4-yl)quinolin-8-yl)piperidin-4-yl)methylcarbamate

Sources & evidence

ORD record
ord-d3f0e1b82b4346a1a08adc2a454ce267
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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