Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Nitrophenylboronic Acid → N-(3-methyl-5-isoxazolyl)-5-(3-nitrophenyl)thiophene-2-sulfonamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Nitrophenylboronic Acid | HCID 1677 | — |
| 반응물 | N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide | HCID 22998516 | — |
| 생성물 | N-(3-methyl-5-isoxazolyl)-5-(3-nitrophenyl)thiophene-2-sulfonamide | HCID 22998512 | 21% |
반응 단계
N-(3-methyl-5-isoxazolyl)-5-(3-nitrophenyl)thiophene-2-sulfonamide was prepared in the same manner as described in Example 32C from 3-nitrobenzene boronic acid (362 mg, 2.17 mmol) and N-(3-methyl-5-isoxazolyl)-5-bromothiophene-2-sulfonamide (700 mg, 2.17 mmol). Purification by column chromatography using 10% MeOH/CHCl3 gave 166 mg of the pure sulfonamide (21% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05594021 |
| 출처 데이터셋 | uspto-grants-1997_01 |
| ORD ID | ord-01a0424ff4f7464d85f80cd1ae1faf43 |
| 출처 메모 | uspto-grants-1997_01 |