反应详情

0.08 g of propionyl chloride is added to a solution of 0.33 g of the compound obtained in EXAMPLE 3 in 3 ml of pyridine and the reaction mixture is stirred for 1 hour at RT. It is poured into water, extracted with AcOEt, dried over sodium sulfate and evaporated under vacuum. The residue is chromatographed on silica using a DCM/AcOEt mixture (98/2; v/v) as the eluent to give the expected product after crystallization from a DCM/iso ether mixture. m=0.18 g. M.p.=188° C.

1. extractionextracted with AcOEt
2. dry with materialdried over sodium sulfate
3. customevaporated under vacuum
4. customThe residue is chromatographed on silica using a DCM/AcOEt mixture (98/2; v/v) as the eluent