反应详情

N-iodosuccinimide (148.75 g, 0.661 mol) was added to a stirred solution of 2-n-butyl-4-hydroxymethylimidazole (100.78 g, 0.652 mol) in 500 ml of absolute ethanol. After 20 minutes the solution was heated to 40°-45° C. for 45 minutes, diluted with 2.5 L of water, and chilled. The crystalline product which formed was collected by filtration, washed with water, and dried to give 1.74.5 g (95%) of crystals; mp 166°-166.5° C.

1. temperatureAfter 20 minutes the solution was heated to 40°-45° C. for 45 minutes
2. temperaturechilled
3. customThe crystalline product which formed
4. filtrationwas collected by filtration
5. washwashed with water
6. customdried