4-Nitrobenzenesulfonyl chloride → 3-Amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydro-1-(4-nitrobenzenesulfonyl)indol-2-one

HRID 234501Notes

Reaction equation

HRID 234501 reaction equation
[NH2:1][C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[NH:4][C:3]1=[O:12].[N+:20]([C:23]1[CH:28]=[CH:27][C:26]([S:29](Cl)(=[O:31])=[O:30])=[CH:25][CH:24]=1)([O-:22])=[O:21]>>[NH2:1][C:2]1([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][C:14]=2[Cl:19])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([Cl:11])[CH:9]=2)[N:4]([S:29]([C:26]2[CH:25]=[CH:24][C:23]([N+:20]([O-:22])=[O:21])=[CH:28][CH:27]=2)(=[O:30])=[O:31])[C:3]1=[O:12]

Participants

3

Reactant 2

HCID 74044-Nitrobenzenesulfonyl chlorideHCID 190763763-Amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one

Product 1

HCID 190765283-Amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydro-1-(4-nitrobenzenesulfonyl)indol-2-one

Procedure

This compound is prepared according to the procedure described in EXAMPLE 1 from 10 g of 3-amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one and 7.55 g of 4-nitrobenzenesulfonyl chloride. The expected product is obtained after crystallization from a DCM/iso ether mixture. m=14 g. M.p.=202° C.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-f3783bbf4fa1492598583b4a2ddbec1d
Source dataset
uspto-grants-1997_01
Patent number
US05594023

Reaction notes

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