HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(3,3-Diethyl-ureido)-benzenesulfonyl chloride → 3-Amino-4,5-dichloro-1-[4-(N',N'-diethylureido)-benzenesulfonyl]-1,3-dihydro-3-phenylindol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(3,3-Diethyl-ureido)-benzenesulfonyl chloride | HCID 2758245 | — |
| Reactant | 3-Amino-4,5-dichloro-1,3-dihydro-3-phenylindol-2-one | HCID 19076566 | — |
| Solvent | Dichloromethane ethylacetate | HCID 21226138 | — |
| Product | 3-Amino-4,5-dichloro-1-[4-(N',N'-diethylureido)-benzenesulfonyl]-1,3-dihydro-3-phenylindol-2-one | HCID 19076415 | — |
Reaction Steps
This compound is prepared according to the procedure described in EXAMPLE 1 from 0.4 g of 3-amino-4,5-dichloro-1,3-dihydro-3-phenylindol-2-one and 0.4 g of 4-(N',N'-diethylureido)benzenesulfonyl chloride. Chromatography on silica using a DCM/AcOEt mixture (85/15; v/v) as the eluent gives the expected product after crystallization from a DCM/iso ether mixture. m=0.46 g. M.p.=161°-163° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05594023 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-a4c467c0eb9b4fb2a17c11919a135224 |
| Source note | uspto-grants-1997_01 |