2,4-Dimethoxybenzenesulfonyl chloride → 3-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydro-1-(2,4-dimethoxybenzenesulfonyl)indol-2-one

HRID 234515Notes

Reaction equation

HRID 234515 reaction equation
[NH2:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][CH2:12][CH3:13])[CH:9]=2)[NH:4][C:3]1=[O:14].[CH3:22][O:23][C:24]1[CH:29]=[C:28]([O:30][CH3:31])[CH:27]=[CH:26][C:25]=1[S:32](Cl)(=[O:34])=[O:33]>>[NH2:1][C:2]1([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[Cl:21])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][CH2:12][CH3:13])[CH:9]=2)[N:4]([S:32]([C:25]2[CH:26]=[CH:27][C:28]([O:30][CH3:31])=[CH:29][C:24]=2[O:23][CH3:22])(=[O:34])=[O:33])[C:3]1=[O:14]

Participants

3

Reactant 2

HCID 27346262,4-Dimethoxybenzenesulfonyl chlorideHCID 190763873-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydroindol-2-one

Product 1

HCID 190763773-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydro-1-(2,4-dimethoxybenzenesulfonyl)indol-2-one

Procedure

This compound is prepared according to the procedure described in EXAMPLE 1 from 3-amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydroindol-2-one and 2,4-dimethoxybenzenesulfonyl chloride. The expected product is obtained after crystallization from a DCM/hexane/iso ether mixture. M.p.=196°-198° C.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-f635adf5c56a458fa7c84053543e6fbb
Source dataset
uspto-grants-1997_01
Patent number
US05594023

Reaction notes

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