HRID234521

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6367

Acetyl chloride

C2H3ClO

结构：CCOc1ccc2c(c1)C(N)(c1ccccc1Cl)C(=O)N2S(=O)(=O)c1ccc(NC(=O)N(CC)CC)cc1

HCID19076405

未命名化合物

PRODUCTS

生成物

结构：CCOc1ccc2c(c1)C(NC(C)=O)(c1ccccc1Cl)C(=O)N2S(=O)(=O)c1ccc(NC(=O)N(CC)CC)cc1

HCID19076392

未命名化合物

PROCEDURE

实验过程

This compound is prepared according to the procedure described in EXAMPLE 2 from the compound obtained in EXAMPLE 87 and acetyl chloride. Crystallization from a DCM/iso ether mixture gives the expected product, which crystallizes with 0.25 mol of iso ether.

WORKUP

后处理

customThis compound is prepared
customCrystallization from a DCM/iso ether mixture

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cf90f52d331d4d0bab19394b1177e8d1
来源数据集: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05594023
来源说明: uspto-grants-1997_01

反应 SMILES

[NH2:1][C:2]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[Cl:38])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][CH2:12][CH3:13])[CH:9]=2)[N:4]([S:14]([C:17]2[CH:22]=[CH:21][C:20]([NH:23][C:24]([N:26]([CH2:29][CH3:30])[CH2:27][CH3:28])=[O:25])=[CH:19][CH:18]=2)(=[O:16])=[O:15])[C:3]1=[O:31].[C:39](Cl)(=[O:41])[CH3:40]>>[C:39]([NH:1][C:2]1([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=2[Cl:38])[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([O:11][CH2:12][CH3:13])[CH:9]=2)[N:4]([S:14]([C:17]2[CH:18]=[CH:19][C:20]([NH:23][C:24]([N:26]([CH2:29][CH3:30])[CH2:27][CH3:28])=[O:25])=[CH:21][CH:22]=2)(=[O:16])=[O:15])[C:3]1=[O:31])(=[O:41])[CH3:40]