3-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]aniline → {3-[5-(2-Chloro-4-pyrimidinyl)-2-(1,1-dimethylethyl)-1,3-thiazol-4-yl]-2,4-difluorophenyl}amine
Reaction equation
[Cl:1][c:2]1[n:3][c:4](-[c:5]2[s:6][c:7]([CH:8]([CH3:9])[CH3:10])[n:11][c:12]2-[c:13]2[cH:14][c:15]([NH2:19])[cH:16][cH:17][cH:18]2)[cH:20][cH:21][n:22]1.[Cl:23][c:24]1[n:25][cH:26][cH:27][c:28](-[c:30]2[c:31](-[c:39]3[c:40]([F:53])[c:41]([NH:46][C:47](=[O:48])[O:49][CH2:50][CH:51]=[CH2:52])[cH:42][cH:43][c:44]3[F:45])[n:32][c:33]([C:35]([CH3:36])([CH3:37])[CH3:38])[s:34]2)[n:29]1>>[Cl:23][c:24]1[n:25][cH:26][cH:27][c:28](-[c:30]2[c:31](-[c:39]3[c:40]([F:53])[c:41]([NH2:46])[cH:42][cH:43][c:44]3[F:45])[n:32][c:33]([C:35]([CH3:36])([CH3:37])[CH3:38])[s:34]2)[n:29]1Participants
3
Sources & evidence
- ORD record
- ord-80a9402a3693405da38d9b0c878acc1e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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