4-(3,3-Diethyl-ureido)-benzenesulfonyl chloride → 3-Amino-5-chloro-3-(2-chlorophenyl)-1-[4-(N',N'-diethylureido)benzenesulfonyl]-1,3-dihydroindol-2-one

Participants

Reaction Steps

This compound is prepared according to the procedure described in EXAMPLE 30 from 0.293 g of 3-amino-5-chloro-3-(2-chlorophenyl)-1,3-dihydroindol-2-one, (-) isomer, and 0.290 g of 4-(N',N'-diethylureido)benzenesulfonyl chloride. Chromatography twice on silica using a DCM/AcOEt mixture (90/10; v/v) as the eluent gives 0.065 g of the expected product after crystallization and then recrystallization from a DCM/iso ether mixture and drying at 90° C. under vacuum. αd25 =-133° (c=0.24; chloroform).

Provenance & Evidence