HRID234532

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：COc1cc(C(=O)OCc2ccccc2)ccc1S(=O)(=O)Cl

HCID15231551

未命名化合物

反应SMILES：CNC1(c2ccccc2Cl)C(=O)Nc2ccc(Cl)cc21

HCID19076510

未命名化合物

PRODUCTS

产物

反应SMILES：CNC1(c2ccccc2Cl)C(=O)N(S(=O)(=O)c2ccc(C(=O)OCc3ccccc3)cc2OC)c2ccc(Cl)cc21

HCID19076416

未命名化合物

收率 86.2%

PROCEDURE

实验过程

This compound is prepared according to the procedure described in step A of EXAMPLE 28 from 6 g of 5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-(methylamino)indol-2-one and 6.66 g of benzyl 4-chlorosulfonyl-3-methoxybenzoate. 10.3 g of the expected product are obtained after crystallization from iso ether.

WORKUP

后处理

customThis compound is prepared

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-dfcd0f70a36e4b9e8d2ae71f9c215d24
来源数据集: uspto-grants-1997_01
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US05594023
来源说明: uspto-grants-1997_01

反应SMILES

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20])[NH:12][CH3:13].Cl[S:22]([C:25]1[CH:40]=[CH:39][C:28]([C:29]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:30])=[CH:27][C:26]=1[O:41][CH3:42])(=[O:24])=[O:23]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:22]([C:25]1[CH:40]=[CH:39][C:28]([C:29]([O:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[O:30])=[CH:27][C:26]=1[O:41][CH3:42])(=[O:24])=[O:23])[C:6](=[O:11])[C:5]2([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20])[NH:12][CH3:13]