Benzyl 4-chlorosulfonyl-3-methoxybenzoate → Benzyl 4-[[5-chloro-3-(2-chlorophenyl)-2,3-dihydro-3-(methylamino)-2-oxoindol-1-yl]sulfonyl]-3-methoxybenzoate

HRID 234532Notes

Reaction equation

HRID 234532 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20])[NH:12][CH3:13].Cl[S:22]([C:25]1[CH:40]=[CH:39][C:28]([C:29]([O:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)=[O:30])=[CH:27][C:26]=1[O:41][CH3:42])(=[O:24])=[O:23]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([S:22]([C:25]1[CH:40]=[CH:39][C:28]([C:29]([O:31][CH2:32][C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)=[O:30])=[CH:27][C:26]=1[O:41][CH3:42])(=[O:24])=[O:23])[C:6](=[O:11])[C:5]2([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[Cl:20])[NH:12][CH3:13]

Participants

3

Reactant 2

HCID 15231551Benzyl 4-chlorosulfonyl-3-methoxybenzoateHCID 190765105-Chloro-3-(2-chlorophenyl)-1,3-dihydro-3-(methylamino)indol-2-one

Product 1

HCID 19076416Benzyl 4-[[5-chloro-3-(2-chlorophenyl)-2,3-dihydro-3-(methylamino)-2-oxoindol-1-yl]sulfonyl]-3-methoxybenzoateYield 86.2%

Procedure

This compound is prepared according to the procedure described in step A of EXAMPLE 28 from 6 g of 5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-(methylamino)indol-2-one and 6.66 g of benzyl 4-chlorosulfonyl-3-methoxybenzoate. 10.3 g of the expected product are obtained after crystallization from iso ether.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-dfcd0f70a36e4b9e8d2ae71f9c215d24
Source dataset
uspto-grants-1997_01
Patent number
US05594023

Reaction notes

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