HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Acetyl-2,3-dihydro-1H-indole-5-sulfonyl chloride → 1-[(1-Acetylindolin-5-yl)sulfonyl]-5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one hemihydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Acetyl-2,3-dihydro-1H-indole-5-sulfonyl chloride | HCID 14024596 | — |
| Reactant | 5-Chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one | HCID 19076606 | — |
| Product | 1-[(1-Acetylindolin-5-yl)sulfonyl]-5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one hemihydrate | HCID 88358341 | 84.5% |
Reaction Steps
This compound is prepared according to the procedure described in EXAMPLE 222 from 1 g of 5-chloro-3-(2-chlorophenyl)-1,3-dihydro-3-[(3-methoxypropyl)amino]indol-2-one and 0.711 g of 1-acetylindoline-5-sulfonyl chloride. 0.921 g of the expected product is obtained after crystallization from a DCM/iso ether mixture. M.p=158°-162° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05594023 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-389b5bb3986f4c4d87002c1f10712666 |
| Source note | uspto-grants-1997_01 |