反应详情

0.52 g of propionyl chloride is added at RT to a solution of 1.323 g of the compound obtained in EXAMPLE 89 in 5 ml of pyridine and the mixture is stirred for 24 hours. It is concentrated under vacuum, the residue is extracted with AcOEt, the organic phase is washed with water and with a saturated solution of NaCl and dried over sodium sulfate and the solvent is evaporated off under vacuum. The residue is chromatographed on silica using a DCM/AcOEt mixture (90/10; v/v) as the eluent to give 1.3 g of the expected product.

1. concentrationIt is concentrated under vacuum
2. extractionthe residue is extracted with AcOEt
3. washthe organic phase is washed with water and with a saturated solution of NaCl
4. dry with materialdried over sodium sulfate
5. customthe solvent is evaporated off under vacuum
6. customThe residue is chromatographed on silica using a DCM/AcOEt mixture (90/10; v/v) as the eluent