HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → tert-Butyl 4-[[3-amino-3-(2-chlorophenyl)-5-ethoxy-2,3-dihydro-2-oxoindol-1-yl]methyl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Tert-butyl 4-(bromomethyl)benzoate | HCID 11414578 | — |
| Reactant | 3-Amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydroindol-2-one | HCID 19076387 | — |
| Solvent | Ethyl acetate hexane | HCID 21226206 | — |
| Product | tert-Butyl 4-[[3-amino-3-(2-chlorophenyl)-5-ethoxy-2,3-dihydro-2-oxoindol-1-yl]methyl]benzoate | HCID 19076455 | 64.7% |
Reaction Steps
This compound is prepared according to the procedure described in EXAMPLE 93 from 1 g of 3-amino-3-(2-chlorophenyl)-5-ethoxy-1,3-dihydroindol-2-one and 0.984 g of tert-butyl 4-bromomethylbenzoate. Chromatography on silica using DCM and then a DCM/AcOEt mixture (70/30; v/v) as the eluent gives 1.053 g of the expected product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05594023 |
| Source dataset | uspto-grants-1997_01 |
| ORD ID | ord-87b3c295a0f14ff8bdbe6bc9ce903e65 |
| Source note | uspto-grants-1997_01 |